Antibody-Dependent Cellular Cytotoxicity and Skin Disease

Natural and Cytotoxicity Antibody-Dependent Cellular of Polymorphonuclear Leukocytes

OHARA, M., SHIRADO, M., MIYATA, M., SAKUMA, H., NANAMIYA, M., YOSHIDA, N., YOSHIDA, H. and KASUKAWA, R. Natural and Antibody-Dependent Cellular Cytotoxicity o f Polymorphonuclear Luekocytes. Tohoku J. exp. Med., 1983, 140 (1), 59-66 Cytotoxic activity of polymorphonuclear leukocytes (PMN) in the peripheral blood of patients with various diseases was demonstrated to K562 cells (natural cytotoxic...

Antibody-dependent and PHA-induced cellular cytotoxicity in rheumatoid arthritis.

One hundred and thirty nine observations of antibody-dependent cell mediated cytotoxicity (ADCC) were made on 77 with rheumatoid arthritis (RA) and 17 healthy controls. There were no differences in ADCC between these 2 groups or within the RA group with regard to disease activity, duration, seropositivity, or drug treatment. Sixty observations of phytohaemagglutinin induced cytotoxicity were ma...

GM-CSF Enhances 3F8 Monoclonal Antibody-Dependent Cellular Cytotoxicity

3F8 is a murine monoclonal IgG3 antibody specific for the tumor-associated antigen ganglioside G . Previous in vitro studies suggest that tumor regressions observed in a phase I clinical trial of 3F8 may be attributable to complement activation by 3F8 and to 3F8-dependent cellular cytotoxicity (ADCC) with lymphocytes. We now describe 3F8-mediated ADCC of G -positive tumor targets (melanoma and ...

NK Cell-Mediated Antibody-Dependent Cellular Cytotoxicity in Cancer Immunotherapy

Natural killer (NK) cells play a major role in cancer immunotherapies that involve tumor-antigen targeting by monoclonal antibodies (mAbs). NK cells express a variety of activating and inhibitory receptors that serve to regulate the function and activity of the cells. In the context of targeting cells, NK cells can be "specifically activated" through certain Fc receptors that are expressed on t...

Antibody-Dependent Cellular Cytotoxicity of Within Peripheral Blood Mononuclear Cells,